Geoclock®

Press coated tablet (tab-in-tab)

Customisable oral chronotherapy

 

Geoclock® (press coated tablet or tab-in-tab technology) allows for timed release of drugs that is independent of food or pH.

Geoclock® is a validated oral drug delivery technology that can be used to release the drug from the tablet after a pre-determined lag-time that is independent of food or pH. Geoclock® can additionally be used for multiple pulse delivery of one or more drugs with pre-determined time intervals between the pulses, or to target colonic release of drugs. Where more than one drug is included, the delivery profile can be different for each active pharmaceutical ingredient. Geoclock® is easily manufactured using conventional production equipment, minimising the need for capital investment.

Skyepharma - Controlled release technology Geoclock®- press coated tablet

How Geoclock Works

Geoclock® is a dry-coated tablet with an active drug core inside an outer tablet layer comprising a mixture of hydrophobic wax and brittle material. This configuration generates a pH-independent lag-time prior to the release of the active drug. After the pre-defined and configurable lag-time the inner tablet releases the active drug either as a burst or with a controlled release pattern.

The controlled release characteristics of the inner core can be modified to achieve the desired profile.

Benefits of Geoclock

Geomatrix® is a highly versatile platform that can be used to create a wide variety of different release profiles. Examples of the application of Geomatrix® include:

  • A wide range of release profiles
  • Controlled release of both poorly and highly soluble drugs
  • Zero order and bi-phasic release of drugs (either rapid then slow or ascending profiles)
  • Release of two or more drugs at different rates
  • Simultaneous or phased release of several drugs at individualised release rates from a single tablet

Geomatrix® is currently used in 8 products that are available in over 80 countries. It uses widely approved GRAS (Generally Recognised as Safe) inert ingredients and is easily manufactured using conventional production equipment.